Water → 2,2-Dimethyl-3-phenylpropanoic acid

HRID 2372708ノート

反応式

HRID 2372708 の反応式
[CH3:1][C:2]([CH3:15])([CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:3]([O:5]CC)=[O:4].[OH-].[K+].O>CO>[CH3:1][C:2]([CH3:15])([CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:3]([OH:5])=[O:4]

参加物

5

反応物 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 4684633Ethyl 2,2-dimethyl-3-phenylpropanoate

生成物 1

HCID 218802,2-Dimethyl-3-phenylpropanoic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of 1 g (20 mmol) of ethyl 2,2-dimethyl-3-phenylpropionate (stage 1) and 3.5 g (61 mmol) of potassium hydroxide in 15 ml of methanol was heated under reflux for 2 hours. Thereafter, 50 ml of water were added and the mixture was extracted twice with ether. The aqueous phase was acidified with concentrated hydrochloric acid and extracted again with ether, the organic phase was dried over magnesium sulfate and the solvent was stripped off in vacuo.

後処理

  1. temperatureunder reflux for 2 hours
  2. extractionthe mixture was extracted twice with ether
  3. extractionextracted again with ether
  4. dry with materialthe organic phase was dried over magnesium sulfate

出典と根拠

ORDレコード
ord-9969ee1641604da1a0397e24052c7a8b
出典データセット
uspto-grants-1992_03
特許番号
US05100887

反応ノート

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