反应详情

A solution of 1 g (20 mmol) of ethyl 2,2-dimethyl-3-phenylpropionate (stage 1) and 3.5 g (61 mmol) of potassium hydroxide in 15 ml of methanol was heated under reflux for 2 hours. Thereafter, 50 ml of water were added and the mixture was extracted twice with ether. The aqueous phase was acidified with concentrated hydrochloric acid and extracted again with ether, the organic phase was dried over magnesium sulfate and the solvent was stripped off in vacuo.

1. temperatureunder reflux for 2 hours
2. extractionthe mixture was extracted twice with ether
3. extractionextracted again with ether
4. dry with materialthe organic phase was dried over magnesium sulfate