HCID 19902147, compound → HCID 19902214, compound

HRID 2372715Notes

Reaction equation

HRID 2372715 reaction equation
[CH:1]1([C:4]2[N:8]=[C:7]([C:9]3[N:10]=[CH:11][N:12]4[C:21]5[CH:20]=[CH:19][CH:18]=[C:17]([F:22])[C:16]=5[C:15]5=[N:23][CH2:24][CH2:25][N:14]5[C:13]=34)[O:6][N:5]=2)[CH2:3][CH2:2]1>[O-2].[O-2].[O-2].[Ni+3].[Ni+3].C1C=CC=CC=1>[CH:1]1([C:4]2[N:8]=[C:7]([C:9]3[N:10]=[CH:11][N:12]4[C:21]5[CH:20]=[CH:19][CH:18]=[C:17]([F:22])[C:16]=5[C:15]5=[N:23][CH:24]=[CH:25][N:14]5[C:13]=34)[O:6][N:5]=2)[CH2:3][CH2:2]1

Participants

4

Reactant 1

HCID 19902147HCID 19902147, compound

Product 1

HCID 19902214HCID 19902214, compound

Reagents, catalysts & solvents 2

HCID 10313272Nickel oxide (Ni2O3)CatalystHCID 241BenzeneSolvent

Procedure

A mixture of 5-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-12-fluoro-2,3-dihydrodiimidazo[1,5-a:1',2'-c]quinazoline (2.0 g, 5.9 mmol), nickel peroxide (10 g), and benzene (125 ml) was heated at reflux for 3.5 hours, cooled slightly, and filtered. The filtrate was evaporated to give the title compound as light yellow crystals, m.p. 266°-268° C. (Compound 38).

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 3.5 hours
  3. temperaturecooled slightly
  4. filtrationfiltered
  5. customThe filtrate was evaporated

Sources & evidence

ORD record
ord-ec026918e40646d6b4502e29855d25fd
Source dataset
uspto-grants-1992_03
Patent number
US05100895

Reaction notes

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