Triethylamine → HCID 19902169, compound

Participants

Reaction Steps

A suspension of 2-chloro-6-fluoro-4-(2-hydroxyethylamino)quinazoline (7.0 g, 29 mmol) in dichloromethane (140 ml) was heated at reflux for 4 hours with thionyl chloride (4.2 ml, 58 mmol) and triethylamine (8 ml, 58 mmol). The cooled mixture was evaporated to dryness and extracted with water (80 ml). The acidic water solution was neutralized with 25% aqueous ammonia (approx. 7 ml) and the resulting precipitate was filtered off and dried to give the title compound as light yellow crystals, m.p. 209°-211° C.

Provenance & Evidence