Cyanoacetic acid → HCID 47240101, compound

Participants

Reaction Steps

39.5 g of 2,3-dihydro-5-benzofurancarbaldehyde (prepared according to the process described in J. Org. Chem. (1984), 49, p. 409), 22.7 g of 2-cyanoacetic acid and 4.08 g of ammonium acetate are mixed in 37 ml of pyridine and 210 ml of benzene. The mixture is brought to reflux for 6 hours 30 minutes. The precipitate formed is isolated and then suspended in 600 ml of 6N hydrochloric acid. The solid isolated is filtered off and washed with water and dried in the air.

Provenance & Evidence