Phenethyl bromide → HCID 86744623, compound

Participants

Reaction Steps

cis-N-Phenyl-N-(3-methoxy-4-piperidinyl)propanamide (8, 0.5g, 1.9 mmol) from Example 6, phenylethyl bromide (0.40g, 2.2 mmol) and 2.76g (I9 mmol) of potassium carbonate in 100ml of acetonitrile were heated to reflux overnight. The reaction solution was concentrated under vacuum and the crude residue was purified by chromatography (silica gel; ethyl acetate) to yield 0.43g (62%, Rf 0.326) of pure cis-N-phenyl-N-(1-phenylethyl-3-methoxy-4-piperidinyl) propanamide (I).

Provenance & Evidence