HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2372806Generated: November 2, 2026
Formaldehyde → 1-[4-(pyrrolidinyl)-2-butynyl]-1H-imidazole
https://huagongshe.com/reaction/2372806
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 1-(prop-2-yn-1-yl)-1H-imidazole | HCID 12591942 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 1-[4-(pyrrolidinyl)-2-butynyl]-1H-imidazole | HCID 19902297 | 68.7% |
Reaction Steps
A mixture of 1-(2-propynyl)-1H-imidazole (2.5 g, 0.023 mol), pyrrolidine (2.0 g, 0.026 mol), paraformaldehyde (0.85 , 0.028 mol) and cuprous chloride (30 mg) in dioxane (20 mL) was heated at 50° C. for 4 h. The solvent was evaporated and the residual oil was dissolved in chloroform, filtered, and chromatographed on silica gel to give 2.99 g of 1-[4-(pyrrolidinyl)-2-butynyl]-1H-imidazole as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05100909 |
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| Source dataset | uspto-grants-1992_03 |
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| ORD ID | ord-5b00f6120d124f158a1e97087a11de3f |
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| Source note | uspto-grants-1992_03 |
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