Hydrochloric Acid → HCID 54407608, compound

Participants

Reaction Conditions

Reaction Steps

2.36 g (0.0097 mol) of 4-[(4-hydroxyphenyl)sulfonyl]benzonitrile are added to a solution of 570 mg of potassium hydroxide in 35 ml of water. The solution is kept at room temperature for 15 minutes. After cooling to 0° C., a solution of 1.38 g of N,N-dimethylthiocarbamoyl chloride in 35 ml of acetone is added dropwise. After 4 hours, the reaction mixture is hydrolyzed in a 1 N solution of hydrochloric acid. The solution is extracted with ethyl acetate. The organic phase is washed with water until the pH of the washings is neutral, dried over magnesium sulfate and concentrated to dryness. 3 g (yield: 100%) of the expected product are thus obtained.

Provenance & Evidence