反应详情

50 g (0.256 mol) of 3-hydroxy-4-nitro-phthalide are hydrogenated at 20° C. and at 3 bar using 5 g of Pd/barium sulphate (5%) in 380 ml of ethanol. The mixture is filtered with suction, and 0.308 mol=38.7 ml of phenylacetaldehyde solution are added to the filtrate. The mixture is boiled for 4 hours, the quinolinecarboxylic acid precipitating. It is cooled, filtered with suction and washed with ethanol 28.3 g (44.3% of theory) of a colorless compound of melting point>290° C. are obtained.

1. customare hydrogenated at 20° C. and at 3 bar
2. filtrationThe mixture is filtered with suction, and 0.308 mol=38.7 ml of phenylacetaldehyde solution
3. additionare added to the filtrate
4. temperatureIt is cooled
5. filtrationfiltered with suction
6. washwashed with ethanol 28.3 g (44.3% of theory) of a colorless compound of melting point>290° C.
7. customare obtained