反应详情

0.9 g (8.75 of nitroacetone, 0.58 g (5 mmol) of methyl 3-aminocrotonate and 0.3 ml (5 mmol) of acetic acid are added to 1.17 g (5 mmol) of 3-phenylquinoline-5-aldehyde in 10 ml of ethanol and the mixture is boiled for 1 hour. It is cooled and concentrated. The evaporation residue is purified by means of a silica gel column using chloroform/methanol mixtures. The clean fractions are concentrated, and the evaporation residue is recrystallized from ethyl acetate. 0.6 g of orange-colored crystals of melting point 262° C. are obtained.

1. temperatureIt is cooled
2. concentrationconcentrated
3. customThe evaporation residue is purified by means of a silica gel column
4. concentrationThe clean fractions are concentrated
5. customthe evaporation residue is recrystallized from ethyl acetate