Methyl acetoacetate → HCID 15170334, compound

Participants

Reaction Steps

0.7 g (3 mmol) of 3-phenylquinoline-5-aldehyde in 6 ml of ethanol are boiled with 0.35 g (3 mmol) of methyl acetoacetate and 0.25 g (3 mmol) of 3-aminocrotononitrile for 24 hours. The mixture is cooled and concentrated. The evaporation residue is purified by means of a silica gel column using toluene/ethyl acetate mixtures. The clean fractions are combined and concentrated. 0.5 g of colorless substance of melting point 242° C. are obtained by crystallization from isopropanol.

Provenance & Evidence