HCID 131717218, compound → HCID 178441615, compound

Participants

Reaction Steps

A solution of 2-n-butyl-3-[(2'-(N-triphenylmethyl-tetrazol-5-yl)-biphen-4-yl)-methyl]-5-ethyl-6-methylpyrimidin-4(3H)-one (from Example 5) in 4 mL acetic acid and 2 mL water was stirred at room temperature for 6 hours. The reaction mixture was diluted with brine and extracted three times with ether. The combined organic material was washed with brine, was dried over MgSO4, was stripped of solvent in vacuo, and then was MPLC'd in 1 acetic acid/39 hexane/60 ethyl acetate to give the title compound as a white foam. 1H NMR (300 MHz, CDCl3) δ7.87 (m, 1H), 7.58 (m, 1H), 7.49 (m, 1H), 7.40 (m, 1H), 7.02 (4 line m, 4H), 5.19 (br s, 2H), 2.57 (3 line m, 2H), 2.42 (4 line m, 2H), 2.24 (s, 3H), 1.63 (m, 2H), 1.34 (m, 2H), 0.96 (3 line m, 3H), 0.88 (3 line m, 3H); IR (CHCl3) 3420 (br), 3020, 1645, 1530, 1120 cm-1 ; FABMS: 429 (M+1).

Provenance & Evidence