Methanol → 2-n-Butyl-3-(2'-cyanobiphen-4-yl)methyl-5-ethoxycarbonylpyrimidin-4(3H)-one

HRID 2372844노트

반응식

HRID 2372844 반응식
[C:1]([C:3]1[CH:22]=[CH:21][CH:20]=[CH:19][C:4]=1[C:5]1[CH:10]=[CH:9][C:8]([CH2:11][NH:12][C:13](=[NH:18])[CH2:14][CH2:15][CH2:16][CH3:17])=[CH:7][CH:6]=1)#[N:2].C([O:25][CH:26]=[C:27]([C:33](OCC)=O)[C:28]([O:30][CH2:31][CH3:32])=[O:29])C.CO>CN(C=O)C>[CH2:14]([C:13]1[N:12]([CH2:11][C:8]2[CH:9]=[CH:10][C:5]([C:4]3[CH:19]=[CH:20][CH:21]=[CH:22][C:3]=3[C:1]#[N:2])=[CH:6][CH:7]=2)[C:26](=[O:25])[C:27]([C:28]([O:30][CH2:31][CH3:32])=[O:29])=[CH:33][N:18]=1)[CH2:15][CH2:16][CH3:17]

참가 물질

5

반응물 3

HCID 887MethanolHCID 6871Diethyl (ethoxymethylene)malonateHCID 178446842HCID 178446842, 화합물

생성물 1

HCID 679401702-n-Butyl-3-(2'-cyanobiphen-4-yl)methyl-5-ethoxycarbonylpyrimidin-4(3H)-one

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

The title compound is prepared by stirring one equivalent of N-[(2'-cyanobiphen-4-yl)-methyl]valeramidine with diethyl ethoxymethylenemalonate (Aldrich) in a suitable solvent such as methanol or DMF. After the initial adduct is formed, one equivalent of base such as sodium methoxide is added then the material is stirred for an additional period of time, possibly with heating. Standard workup procedures appropriate to the chosen reaction solvent should be followed.

출처 및 근거

ORD 기록
ord-422f310146f24dc4b1d606d42c165cdf
출처 데이터셋
uspto-grants-1992_03
특허 번호
US05100897

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