Azido(trimethyl)stannane → HCID 178441661, compound

HRID 2372845Notes

Reaction equation

HRID 2372845 reaction equation
[CH2:1]([C:5]1[N:10]([CH2:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[C:24]#[N:25])=[CH:14][CH:13]=2)[C:9](=[O:26])[C:8]([C:27]([O:29][CH2:30][CH3:31])=[O:28])=[CH:7][N:6]=1)[CH2:2][CH2:3][CH3:4].C[Sn]([N:36]=[N+:37]=[N-:38])(C)C>C1(C)C=CC=CC=1>[CH2:1]([C:5]1[N:10]([CH2:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[C:24]3[NH:38][N:37]=[N:36][N:25]=3)=[CH:14][CH:13]=2)[C:9](=[O:26])[C:8]([C:27]([O:29][CH2:30][CH3:31])=[O:28])=[CH:7][N:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 5104973Azido(trimethyl)stannaneHCID 679401702-n-Butyl-3-(2'-cyanobiphen-4-yl)methyl-5-ethoxycarbonylpyrimidin-4(3H)-one

Product 1

HCID 178441661HCID 178441661, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

The title compound is prepared by heating one equivalent of 2-n-butyl-3-(2'-cyanobiphen-4-yl)methyl-5-ethoxycarbonylpyrimidin-4(3H)-one from (from Example 7) with one to four equivalents of trimethylstannyl azide in toluene. After completion of the reaction the trimethylstannyl moiety is removed from the tetrazole moiety by workup with an acidic aqueous solution such as saturated aqueous ammonium chloride.

Workup

  1. customis removed from the tetrazole moiety by workup with an acidic aqueous solution such as saturated aqueous ammonium chloride

Sources & evidence

ORD record
ord-dd7de94cecbe4979a7c5d4cf274368fb
Source dataset
uspto-grants-1992_03
Patent number
US05100897

Reaction notes

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