Hydrochloric Acid → HCID 178437521, compound

Participants

Reaction Conditions

Reaction Steps

125 g of 3-aminocrotonitrile were dissolved in 500 ml of formamide and heated to 100° C. To this were added 155 g of N-cyanoacetyl-N,-propionylhydrazine in such a way that the exothermic reaction had subsided before the next addition. The mixture was then stirred at 120° to 125° C. for 6 hours and allowed to cool. It was then diluted with 1000 ml of water and acidified with concentrated hydrochloric acid. Filtration with suction, washing with water and drying at 100° C. resulted in 141 g of 6-cyano-2-ethyl-7-hydroxy-5-methyl[1,2,4]triazolo-[2,3-a]pyridine. A sample recrystallized from N-methylpyrrolidone melts at 346° to 348° C. and has the following analysis:

Provenance & Evidence