Ammonia → HCID 19902507, compound

Participants

Reaction Conditions

Reaction Steps

272 g of 6-cyano-2-(1-ethylpentyl)-7-hydroxy-5-methyl[1,2,4]triazolo[2,3-a]pyridine were introduced into 250 g of phosphorus oxytrichloride and stirred at 105° C. for 4 hours. Then 250 g of methanol were added dropwise, the mixture was briefly boiled and 250 ml of water were run in. The solution was cooled and, at 10° to 20° C., the pH was adjusted to 7.5 with aqueous ammonia, when the target product precipitated. It was filtered off with suction, washed with water and dried at 50° C. under reduced pressure. 264 g of the compound of the formula ##STR11## were obtained. A sample recrystallized from ethanol/cyclohexane has a melting point of 95° to 96° C. and the following analysis:

Provenance & Evidence