HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → (1s,3s)-3-Phenylcyclobutanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 3-Phenylcyclobutanone | HCID 142963 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (1s,3s)-3-Phenylcyclobutanol | HCID 21876130 | 78.9% |
Reaction Steps
To the solution of 3-phenyl-cyclobutanone (100 mg) in THF (10 mL) was added LiAlH4 (0.2 mL, 2M in THF). The mixture was stirred at rt for 2 h, then 2M NaOH (1 mL) was added. The organic layer was concentrated and purified by PTLC providing the title compound (80 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08642583B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-6169a1c02ff847ff96bc0a3a677f9b64 |
| Source note | uspto-grants-2014_02 |