Acetic Acid → HCID 19790384, compound

HRID 2372924Notes

Reaction equation

HRID 2372924 reaction equation
S(Cl)([Cl:4])(=O)=O.[Cl:6][C:7]1[NH:8][C:9]([C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[C:16]([Cl:21])[CH:15]=2)=[CH:10][C:11]=1[C:12]#[N:13].CCOCC.C(O)(=O)C>CCCCCC>[Cl:6][C:7]1[NH:8][C:9]([C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[C:16]([Cl:21])[CH:15]=2)=[C:10]([Cl:4])[C:11]=1[C:12]#[N:13]

Participants

6

Reactant 4

HCID 176Acetic AcidHCID 3283Diethyl EtherHCID 24648Sulfuryl chlorideHCID 11022008HCID 11022008, compound

Product 1

HCID 19790384HCID 19790384, compound

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent

Conditions

Temperature
0 °C

Procedure

Sulfuryl chloride (1.8 g) is added dropwise to a 0° C. mixture of 2-chloro-5-(3,4-dichlorophenyl)pyrrole-3-carbonitrile, ether (30 mL) and acetic acid (30 mL). After stirring for 2 hours at 0° C., the reaction mixture is poured into an ice-water slurry. The cold mixture is diluted with hexane and the solids are collected and dried to give the title compound as a beige solid (mp >200° C.) which is identified by 13C NMR spectral analysis.

Workup

  1. customthe solids are collected
  2. customdried

Sources & evidence

ORD record
ord-13e678072cb8448f85f006928eb97e14
Source dataset
uspto-grants-1992_03
Patent number
US05101042

Reaction notes

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