Acetophenone → Benzonitrile, 4-(3-oxo-3-phenyl-1-propenyl)-

Participants

Reaction Steps

1 Mol of cyanobenzaldehyde is reacted with 1 mol of acetophenone and sodium hydroxide in ethanol. The resulting 3-(p-cyanophenyl)-3-phenylpropanone is reacted with KHSO4 to obtain p-cyanochalcone. The p-cyanochalcone is hydrogenated in the presence of a platinum catalyst to produce 3-(p-cyanophenyl)-1-phenylpropanone. The resulting compound is reacted with hydrazine and potassium hydroxide in triethylene glycol to produce p-cyanodiphenylpropane. The p-cyanodiphenylpropane is reacted with fuming nitric acid and acetic acid anhydride to produce 1-(p-cyanophenyl)-3-(p-nitrophenyl)-propane.

Provenance & Evidence