HCID 67221538, compound → HCID 178474237, compound

HRID 237312Notes

Reaction equation

HRID 237312 reaction equation
[ClH:1].[C:2]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([N:12]2[CH2:17][CH2:16][O:15][C@H:14]([C@@H:18]([OH:32])[C:19]([NH:21][C:22]3[CH:27]=[CH:26][C:25]([C:28]#[N:29])=[C:24]([CH2:30][NH2:31])[CH:23]=3)=[O:20])[C:13]2=[O:33])=[CH:8][CH:7]=1)(=[O:4])[CH3:3]>CCO>[ClH:1].[C:2]([NH:5][C:6]1[CH:7]=[CH:8][C:9]([N:12]2[CH2:17][CH2:16][O:15][C@H:14]([C@@H:18]([OH:32])[C:19]([NH:21][C:22]3[CH:23]=[C:24]4[C:25](=[CH:26][CH:27]=3)[C:28](=[NH:29])[NH:31][CH2:30]4)=[O:20])[C:13]2=[O:33])=[CH:10][CH:11]=1)(=[O:4])[CH3:3]

Participants

3

Reactant 1

HCID 67221538HCID 67221538, compound

Product 1

HCID 178474237HCID 178474237, compoundYield 79.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Compound 39-6 (1.2 g) was suspended in EtOH (30 mL) and the mixture was refluxed for 6 hours. After cooling, the precipitate was collected by filtration to obtain EXAMPLE 39 (0.95 g) as a colorless amorphous solid.

Workup

  1. temperaturethe mixture was refluxed for 6 hours
  2. temperatureAfter cooling
  3. filtrationthe precipitate was collected by filtration

Sources & evidence

ORD record
ord-2bf581aa9de34e37bd0b25cdc7867edd
Source dataset
uspto-grants-2014_02
Patent number
US08642582B2

Reaction notes

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