HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoic Acid → HCID 178422259, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoic Acid | HCID 243 | — |
| Reactant | Olanzapine | HCID 135398745 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 178422259 | HCID 178422259 | — |
Reaction Steps
To a clear solution of 0.196 g benzoic acid in 5 ml ethyl acetate was added slowly a clear hot solution of 0.5 g olanzapine free base in 10 ml ethyl acetate. After complete addition, slowly, the crystallization process started. Stirring at room temperature was continued for 5 hours. The crystals were isolated by filtration and dried overnight at 50° C. in vacuo. Isolated yield: 0.64 gram (92%). 1H-NMR confirmed the molar ratio olanzapine: acid=1:1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07459449B2 |
| Source dataset | uspto-grants-2008_12 |
| ORD ID | ord-97d95bd667104b48b84532079254b46d |
| Source note | uspto-grants-2008_12 |