HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 4-Chloro-7-nitroquinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 7-Nitroquinazolin-4(3H)-one | HCID 86222800 | — |
| Product | 4-Chloro-7-nitroquinazoline | HCID 830680 | — |
Reaction Steps
To a solution of 7-nitroquinazolin-4(3H)-one (2.0 g, 10.5 mmol) in 40 ml thionyl chloride was added 0.8 ml of DMF and the mixture was heated at reflux overnight then evaporated to dryness to provide crude 4-chloro-7-nitroquinazoline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08642582B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-f0f7d6401cd4487e98e4fe40bbd46dba |
| Source note | uspto-grants-2014_02 |