反应详情

To Compound 99-1 in 15 mL of 7M NH3 in MeOH was added excess Raney Ni (an aq. suspension) and the mixture stirred under a balloon of hydrogen for two hours. The mixture was filtered and evaporated to dryness yielding a white solid. Purification by RP-HPLC yielded 34 mg of EXAMPLE 99 as a white solid after conversion to the HCl salt by the addition of 1N HCl in diethyl ether and evaporation to dryness.

1. filtrationThe mixture was filtered
2. customevaporated to dryness
3. customyielding a white solid
4. customPurification by RP-HPLC