Methanesulfonic Acid → Linaprazan mesylate

Participants

Reaction Steps

110 g 2,3-dimethyl-8-(2,6-dimethylbenzylamino)-N-hydroxyethyl-imidazo[1,2-a]pyridine-6-carboxamide was suspended in 550 ml ethanol. 32 g methanesulphonic acid, diluted with 80 ml ethanol was charged. After rinsing with ethanol (30 ml), the suspension was stirred at room temperature until conversion to 2,3-dimethyl-8-(2,6-dimethylbenzylamino)-N-hydroxyethyl-imidazo[1,2-a]pyridine-6-carboxamide mesylate salt form B was complete. The suspension was cooled to 2° C. at −10° C./h. The crystals were isolated and vacuum dried over the night at 30° C. 133 g of 2,3-dimethyl-8-(2,6-dimethylbenzylamino)-N-hydroxyethyl-imidazo[1,2-a]pyridine-6-carboxamide mesylate salt form B was obtained.

Provenance & Evidence