3-Chlorophenyl pyridyl acetamide → Hydrochloric Acid

Participants

Reaction Steps

Yet another process, published in Journal of Medicinal Chemistry 1996, Vol. (39), (6), 1201-1209, teaches catalytic hydrogenation of a solution of 0.43 gm (1.7 mmole) of 3-chlorophenyl pyridyl acetamide in 15 ml of acetic acid and 0.14 gm of 5% Platinum on carbon at 30-40° C. for 10 hrs. The catalyst was removed by filtration and the solvent acetic acid was evaporated to dryness, excess concentrated hydrochloric acid was added, further evaporated to dryness to give hydrochloride of 3-chlorophenyl-2-piperidyl acetamide hydrochloride.

Provenance & Evidence