Tryptamine → HCID 58101313, compound

Participants

Reaction Steps

1-(4-Chlorophenyl)cyclobutanecarbaldehyde (30 mg, 0.154 mmol) and 2-(1H-indol-3-yl)ethanamine (27.7 mg, 0.17 mmol) were dissolved in dichloromethane (3 mL). Trifluoroacetic acid (88 mg, 0.771 mmol) were added at 0° C. and the reaction mixture was stirred at room temperature over night. The 5% NaHCO3 solution was added. The aqueous layer was extracted with dichloromethane. The combined organic layers were washed successively with 5% NaHCO3 solution and saturated sodium chloride solution, dried (MgSO4) and concentrated in vacuo. Yield: 36 mg (oil, 0.107 mmol, 69%).

Provenance & Evidence