Sodium Acetate → HCID 86602402, compound

Participants

Reaction Steps

A mixture of [4-(2-chloro-4-pyridyl)-1-ethyl-6-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl]methanol (30 mg), pyridinium chlorochromate (34.2 mg), sodium acetate (5.7 mg) in DCM (2 ml) was stirred at room temperature for 2 hours. The reaction mixture was diluted with diethylether and filtrated through celite pad. After evaporation of filtrate, the residue was purified by flash column chromatography on silica gel eluting with a mixture of EtOAc and n-hexane (1:4) to give 4-(2-chloro-4-pyridyl)-1-ethyl-6-methyl-1H-pyrazolo[3,4-b]pyridine-5-carbaldehyde (29 mg) as a white crystal.

Provenance & Evidence