Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl ester → HCID 86602408, compound

Participants

Reaction Steps

A mixture of (2E)-3-[1-ethyl-6-(methoxymethyl)-4-(5-methyl-3-pyridyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-2-propen-1-ol (40 mg), ethyl (triphenylphosphanylidene)-acetate (49 mg), manganese dioxide (103 mg) and DCM (2 ml) was stirred at room temperature for 1 h. The reaction mixture was filtrated through celite pad. The solvent was evaporated and the residue was purified by flash column chromatography on silica gel (CHCl3-MeOH 95:5) to give ethyl (2E,4E)-5-[1-ethyl-6-(methoxymethyl)-4-(5-methyl-3-pyridyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-2,4-pentadienoate (53 mg) as a colorless solid.

Provenance & Evidence