Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Benzoylacetonitrile | HCID 64799 | — |
| Reactant | 2-Methyl-2H-pyrazol-3-ylamine | HCID 136927 | — |
| Reactant | Tetrahydro-2H-pyran-4-carboxaldehyde | HCID 9964078 | — |
| Product | HCID 69186030 | HCID 69186030 | — |
Reaction Steps
A mixture of benzoylacetonitrile (365 mg), tetrahydropyran-4-carbaldehyde (287 mg), 5-amino-1-methylpyrazole (289 mg) in pyridine (7.3 ml) was stirred for 2 days at 110° C. The solvent was removed under reduced pressure. The residue was purified with silica gel column chromatography to give pure 1-ethyl-6-phenyl-4-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile (359 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07459451B2 |
|---|
| Source dataset | uspto-grants-2008_12 |
|---|
| ORD ID | ord-264c8cd5123f4ec0a05a9b408c9dc4ab |
|---|
| Source note | uspto-grants-2008_12 |
|---|
