HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methyl-N,N-diethylbenzamide → 3-[3-(3-hydroxypyrrolidin-1-yl)propyl]-2H-isoquinolin-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methyl-N,N-diethylbenzamide | HCID 75945 | — |
| Reactant | 4-(3-Hydroxypyrrolidin-1-yl)butanenitrile | HCID 23082112 | — |
| Product | 3-[3-(3-hydroxypyrrolidin-1-yl)propyl]-2H-isoquinolin-1-one | HCID 10038891 | 20.2% |
Reaction Steps
By the reaction in the same manner as in Example 1a, using N,N-diethyl-2-methylbenzamide (3.45 g) and 4-(3-hydroxypyrrolidin-1-yl)butyronitrile (1.5 g), 3-[3-(3-hydroxypyrrolidin-1-yl)propyl]-2H-isoquinolin-1-one (536.3 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07459465B2 |
| Source dataset | uspto-grants-2008_12 |
| ORD ID | ord-51da616ac0e745cd9f6e37d192182336 |
| Source note | uspto-grants-2008_12 |