HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N,2,3-tetramethylbenzamide → 3-[2-(3-hydroxypyrrolidin-1-yl)ethyl]-5-methyl-2H-isoquinolin-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N,2,3-tetramethylbenzamide | HCID 22931034 | — |
| Reactant | 3-(3-Hydroxypyrrolidin-1-yl)propanenitrile | HCID 23082099 | — |
| Product | 3-[2-(3-hydroxypyrrolidin-1-yl)ethyl]-5-methyl-2H-isoquinolin-1-one | HCID 10038892 | 5.4% |
Reaction Steps
By the reaction in the same manner as in Example 1a, using N,N-dimethyl-2,3-dimethylbenzamide (4.10 g) and 3-(3-hydroxypyrrolidin-1-yl)propionitrile (1.5 g), 3-[2-(3-hydroxypyrrolidin-1-yl)ethyl]-5-methyl-2H-isoquinolin-1-one (157.5 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07459465B2 |
| Source dataset | uspto-grants-2008_12 |
| ORD ID | ord-f8f87c16007448708c1633a021d72c55 |
| Source note | uspto-grants-2008_12 |