HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N-Diethyl-2,3-dimethylbenzamide → 3-[2-(3-hydroxypyrrolidin-1-yl)ethyl]-2H-isoquinolin-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N-Diethyl-2,3-dimethylbenzamide | HCID 15621069 | — |
| Reactant | 3-(3-Hydroxypyrrolidin-1-yl)propanenitrile | HCID 23082099 | — |
| Product | 3-[2-(3-hydroxypyrrolidin-1-yl)ethyl]-2H-isoquinolin-1-one | HCID 10377810 | 13.5% |
Reaction Steps
By the reaction in the same manner as in Example 1a, using N,N-diethyl-2,3-dimethylbenzamide (4.347 g) and 3-(3-hydroxypyrrolidin-1-yl)propionitrile (1.6 g), 3-[2-(3-hydroxypyrrolidin-1-yl)ethyl]-2H-isoquinolin-1-one (397.6 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07459465B2 |
| Source dataset | uspto-grants-2008_12 |
| ORD ID | ord-a09bb2cc87544dc38230e6bc01e372a8 |
| Source note | uspto-grants-2008_12 |