HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methyl-N,N-diethylbenzamide → 3-[2-(2-hydroxymethylpiperidin-1-yl)ethyl]-2H-isoquinolin-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methyl-N,N-diethylbenzamide | HCID 75945 | — |
| Reactant | 3-(2-Hydroxymethylpiperidin-1-yl)propionitrile | HCID 23082118 | — |
| Product | 3-[2-(2-hydroxymethylpiperidin-1-yl)ethyl]-2H-isoquinolin-1-one | HCID 10401748 | 15.3% |
Reaction Steps
By the reaction in the same manner as in Example 1a, using N,N-diethyl-2-methylbenzamide (3.42 g) and 3-(2-hydroxymethylpiperidin-1-yl)propionitrile (1.51 g), 3-[2-(2-hydroxymethylpiperidin-1-yl)ethyl]-2H-isoquinolin-1-one (392 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07459465B2 |
| Source dataset | uspto-grants-2008_12 |
| ORD ID | ord-857bac65f91c4988b6f689ca1a50c266 |
| Source note | uspto-grants-2008_12 |