HCID 178472494, compound → HCID 178472495, compound

Participants

Reaction Steps

To an argon purged solution of cis/trans-4-(2-benzyloxy-1-benzyloxymethyl-ethoxy)-cyclohexanecarboxylic acid ethyl ester (2.30 g, 5.39 mmol) in acetic acid (54 ml) was added palladium on charcoal 10% (0.57 g). The reaction mixture was purged with hydrogen gas and stirred at room temperature for 3 h under an atmosphere of hydrogen gas. The catalyst was removed by filtration over Decalite. The filtrate was concentrated in vacuo. Flash-chromatography with n-heptane/ethyl acetate as eluent gave the title compound (0.74 g, 56%) as colorless oil. MS m/e: 247 (M+H+)

Provenance & Evidence