3-Bromo-2,2-dimethyl-1-propanol → 3-[1-(3-hydroxy-2,2-dimethylpropyl)piperidin-4-yl]-2H-isoquinolin-1-one

HRID 2373266Notes

Reaction equation

HRID 2373266 reaction equation
Cl.[NH:2]1[CH2:7][CH2:6][CH:5]([C:8]2[NH:9][C:10](=[O:18])[C:11]3[C:16]([CH:17]=2)=[CH:15][CH:14]=[CH:13][CH:12]=3)[CH2:4][CH2:3]1.Br[CH2:20][C:21]([CH3:25])([CH3:24])[CH2:22][OH:23]>>[OH:23][CH2:22][C:21]([CH3:25])([CH3:24])[CH2:20][N:2]1[CH2:7][CH2:6][CH:5]([C:8]2[NH:9][C:10](=[O:18])[C:11]3[C:16]([CH:17]=2)=[CH:15][CH:14]=[CH:13][CH:12]=3)[CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 1425013-Bromo-2,2-dimethyl-1-propanolHCID 230821133-(Piperidin-4-yl)isoquinolin-1(2H)-one hydrochloride

Product 1

HCID 103135603-[1-(3-hydroxy-2,2-dimethylpropyl)piperidin-4-yl]-2H-isoquinolin-1-oneYield 15.2%

Procedure

By the reaction in the same manner as in Example 2a, using 3-(piperidin-4-yl)-2H-isoquinolin-1-one hydrochloride (510 mg) and 3-bromo-2,2-dimethyl-1-propanol (474 mg), 3-[1-(3-hydroxy-2,2-dim ethylpropyl)piperidin-4-yl]-2H-isoquinolin-1-one (92 mg) was obtained.

Workup

  1. customBy the reaction in the same manner as in Example 2a

Sources & evidence

ORD record
ord-22c67bb1d65a4bea852c8d770a393e29
Source dataset
uspto-grants-2008_12
Patent number
US07459465B2

Reaction notes

Loading…