HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N,2,3-tetramethylbenzamide → (R)-3-[3-(2-hydroxymethylpyrrolidin-1-yl)propyl]-5-methyl-2H-isoquinolin-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N,2,3-tetramethylbenzamide | HCID 22931034 | — |
| Reactant | (R)-4-(2-hydroxymethylpyrrolidin-1-yl)butyronitrile | HCID 62733483 | — |
| Product | (R)-3-[3-(2-hydroxymethylpyrrolidin-1-yl)propyl]-5-methyl-2H-isoquinolin-1-one | HCID 10424887 | 7% |
Reaction Steps
By the reaction in the same manner as in Example 1a, using N,N-dimethyl-2,3-dimethylbenzamide (5.8040 g) and (R)-4-(2-hydroxymethylpyrrolidin-1-yl)butyronitrile (2.75 g), (R)-3-[3-(2-hydroxymethylpyrrolidin-1-yl)propyl]-5-methyl-2H-isoquinolin-1-one (344.1 mg) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07459465B2 |
| Source dataset | uspto-grants-2008_12 |
| ORD ID | ord-9594187aab5f4eac909bc4bec93c16ec |
| Source note | uspto-grants-2008_12 |