反应详情

Subsequently, the crystals recovered from the mother liquor of the recrystallization was recrystallized three times from methanol to yield (11.74 g). (−)-3-(1-Benzylpyrrolidin-3-yl)-5-methyl-2H-isoquinolin-1-one D-tartrate (38.8 g) was stirred in methanol (150 ml)-methylene chloride (300 ml), 1N aqueous sodium hydroxide solution (200 ml) and water (100 ml) were added dropwise to alkalify the solution. The methylene chloride layer was partitioned and washed with water, and then dried over magnesium sulfate and concentrated to give (−)-3-(1-benzylpyrrolidin-3-yl)-5-methyl-2H-isoquinolin-1-one (27.5 g).

1. customSubsequently, the crystals recovered from the mother liquor of the recrystallization
2. customwas recrystallized three times from methanol
3. customto yield (11.74 g)
4. additionwere added dropwise
5. customThe methylene chloride layer was partitioned
6. washwashed with water
7. dry with materialdried over magnesium sulfate
8. concentrationconcentrated