HCID 14901692, compound → HCID 58863419, compound

HRID 2373295Notes

Reaction equation

HRID 2373295 reaction equation
C([N:3]([CH2:14][CH3:15])[C:4](=[O:13])[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([Cl:11])[C:6]=1[CH3:12])C.[OH:16][CH2:17][C@H:18]1[CH2:22][CH2:21][CH2:20][N:19]1[CH2:23]CC(N(OC)C)=O>>[Cl:11][C:7]1[CH:8]=[CH:9][CH:10]=[C:5]2[C:6]=1[CH:12]=[C:14]([CH2:15][CH2:23][N:19]1[CH2:20][CH2:21][CH2:22][C@@H:18]1[CH2:17][OH:16])[NH:3][C:4]2=[O:13]

Participants

3

Reactant 2

HCID 14901692HCID 14901692, compoundHCID 58863439HCID 58863439, compound

Product 1

HCID 58863419HCID 58863419, compoundYield 14.2%

Procedure

In the same manner as in Example 16b and using N,N-diethyl-3-chloro-2-methylbenzamide (3.35 g) and (R)-3-(2-hydroxymethylpyrrolidin-1-yl)-N-methoxy-N-methylpropanamide (3.22 g), (R)-5-chloro-3-[2-(2-hydroxymethylpyrrolidin-1-yl)ethyl]-2H-isoquinolin-1-one (645 mg) was obtained.

Sources & evidence

ORD record
ord-2bb8e78584c648ae83ed67f26eba65c2
Source dataset
uspto-grants-2008_12
Patent number
US07459465B2

Reaction notes

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