Hydrochloric Acid → HCID 11454476, compound

Participants

Reaction Steps

To a solution of 0.1 g (0.196 mmol) of ethyl 5-[5′-fluoro-2′-(2,2,3,3,4,4,4-heptafluorobutyloxy)biphenyl-3-yl]2H-1,2,4-triazole-3-carboxylate (prepared according to procedures described in Reference Example 3, Step B) in 1.4 mL of methanol was added 0.59 mL (0.59 mmol) of a 1N aqueous solution of NaOH and the reaction mixture was stirred at rt for 23 hr. The pH of the reaction mixture was adjusted to pH=4-5 with 1N HCl solution and the mixture was extracted with EtOAc. The organic fractions were dried (Na2SO4), filtered and the filtrate was concentrated. The residue was purified by chromatography (silica, CH2Cl2:acetone 9:1, then CH3OH: CH2Cl2 1 to 10% linear gradient) to give the title compound.

Provenance & Evidence