2-Amino-5-fluorobenzoic acid → Methyl 2-amino-5-fluorobenzoate

HRID 2373352Notes

Reaction equation

HRID 2373352 reaction equation
[NH2:1][C:2]1[CH:11]=[CH:10][C:9](OC)=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].NC1C=CC([F:24])=CC=1C(O)=O>>[NH2:1][C:2]1[CH:11]=[CH:10][C:9]([F:24])=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5]

Participants

3

Reactant 2

HCID 1014122-Amino-5-fluorobenzoic acidHCID 13052275Methyl 2-amino-5-methoxybenzoate

Product 1

HCID 2783401Methyl 2-amino-5-fluorobenzoate

Procedure

In a manner similar to that described above for methyl 2-amino-5-methoxybenzoate, 7.82 g of 2-amino-5-fluorobenzoic acid was converted to i-f (40%): MS m/z═170 (M+H).

Sources & evidence

ORD record
ord-9cf780086d334a5aa6c887dec2db4564
Source dataset
uspto-grants-2008_12
Patent number
US07459448B2

Reaction notes

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