HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → N-(10-Iodo-6oxo-6,7-dihydro-5H-benzo[b]pyrimido[4,5-d]azepin-2-yl)-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Benzoyl chloride | HCID 7412 | — |
| Reactant | 2-Amino-10-iodo-5H,7H-benzo[b]pyrimido[4,5-d]azepin-6-one | HCID 59851021 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | N-(10-Iodo-6oxo-6,7-dihydro-5H-benzo[b]pyrimido[4,5-d]azepin-2-yl)-benzamide | HCID 59851025 | — |
Reaction Conditions
| Temperature | 110 °C |
|---|
Reaction Steps
2-Amino-10-iodo-5H,7H-benzo[b]pyrimido[4,5-d]azepin-6-one (I-51) (69.7 mg, 0.20 mmol) was dissolved in pyridine (800 μL) and benzoyl chloride (23 mL, 0.20 mmol). The mixture was stirred at 110° C. for 1 h, then cooled to 22° C. Et2O was added and the product was filtered from the solution to give I-83 (37%): MS (FA) Rt═1.49 min, m/z═457 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07459448B2 |
| Source dataset | uspto-grants-2008_12 |
| ORD ID | ord-0a100ef74e764f648c17c2c1e94fa6b1 |
| Source note | uspto-grants-2008_12 |