HuagongsheHuagongshe Chemistry Print Report · For research reference only
8-chloro-4-dimethylaminomethylene-3,4-dihydro-1H-benzo[b]azepine-2,5-dione → 9-Chloro-2-(3-methoxy-phenylamino)-5H,7H-benzo[b]pyrimido[4,5-d]azepin-6-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 8-chloro-4-dimethylaminomethylene-3,4-dihydro-1H-benzo[b]azepine-2,5-dione | HCID 66934877 | — |
| Reactant | 1-(3-Methoxyphenyl)guanidine | HCID 178491133 | — |
| Product | 9-Chloro-2-(3-methoxy-phenylamino)-5H,7H-benzo[b]pyrimido[4,5-d]azepin-6-one | HCID 56946582 | — |
Reaction Steps
In a manner similar to that described for method I, 8-chloro-4-dimethylaminomethylene-3,4-dihydro-1H-benzo[b]azepine-2,5-dione (v-j) and 1-(3-methoxyphenyl)guanidine were converted to I-15 (25%): HRMS Calcd. for C19H15ClN4O2: 367.0961, Found 367.0961.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07459448B2 |
| Source dataset | uspto-grants-2008_12 |
| ORD ID | ord-8c26889900e0480a8bd6039273cac0da |
| Source note | uspto-grants-2008_12 |