HuagongsheHuagongshe Chemistry Print Report · For research reference only
Guanidine, 1,1-dimethyl-, sulfate → 9-Chloro-2-dimethylamino-5H,7H-benzo[b]pyrimido[4,5-d]azepin-6-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Guanidine, 1,1-dimethyl-, sulfate | HCID 220673 | — |
| Reactant | 8-chloro-4-dimethylaminomethylene-3,4-dihydro-1H-benzo[b]azepine-2,5-dione | HCID 66934877 | — |
| Product | 9-Chloro-2-dimethylamino-5H,7H-benzo[b]pyrimido[4,5-d]azepin-6-one | HCID 59852003 | — |
Reaction Steps
In a manner similar to that described for method I, 8-chloro-4-dimethylaminomethylene-3,4-dihydro-1H-benzo[b]azepine-2,5-dione (v-j) and 1,1-dimethylguanidine sulfate were converted to I-22 (42%): HRMS Calcd. for C14H13ClN4O: 289.0856, Found 289.0843.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07459448B2 |
| Source dataset | uspto-grants-2008_12 |
| ORD ID | ord-12425cbb78294f00af3b26baea05d869 |
| Source note | uspto-grants-2008_12 |