HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-dimethylaminomethylene-3,4-dihydro-1H-benzo[b]azepine-2,5-dione → 2-(3,4-Dimethoxy-phenylamino)-5H,7H-benzo[b]pyrimido[4,5-d]azepin-6-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-dimethylaminomethylene-3,4-dihydro-1H-benzo[b]azepine-2,5-dione | HCID 66934763 | — |
| Reactant | HCID 178492307 | HCID 178492307 | — |
| Product | 2-(3,4-Dimethoxy-phenylamino)-5H,7H-benzo[b]pyrimido[4,5-d]azepin-6-one | HCID 56946481 | — |
Reaction Steps
In a manner similar to that described for method I, 4-dimethylaminomethylene-3,4-dihydro-1H-benzo[b]azepine-2,5-dione (v-c) and N-(3,4-dimethoxyphenyl)guanidine nitrate were converted to I-27 (58%): HRMS Calcd. for C20H18N4O3: 363.1457, Found 363.1441.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07459448B2 |
| Source dataset | uspto-grants-2008_12 |
| ORD ID | ord-544887aded204b909022d231663aab53 |
| Source note | uspto-grants-2008_12 |