8-chloro-4-dimethylaminomethylene-3,4-dihydro-1H-benzo[b]azepine-2,5-dione → HCID 59851292, compound

HRID 2373400Notes

Reaction equation

HRID 2373400 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[C:11](=O)[C:10](=[CH:13]N(C)C)[CH2:9][C:8](=[O:17])[NH:7][C:6]=2[CH:18]=1.[N+]([O-])(O)=O.[O:23]1[C:28]2[CH:29]=[CH:30][C:31]([NH:33][C:34]([NH2:36])=[NH:35])=[CH:32][C:27]=2[O:26][CH2:25][CH2:24]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[C:11]3[N:35]=[C:34]([NH:33][C:31]4[CH:30]=[CH:29][C:28]5[O:23][CH2:24][CH2:25][O:26][C:27]=5[CH:32]=4)[N:36]=[CH:13][C:10]=3[CH2:9][C:8](=[O:17])[NH:7][C:6]=2[CH:18]=1

Participants

3

Reactant 2

HCID 669348778-chloro-4-dimethylaminomethylene-3,4-dihydro-1H-benzo[b]azepine-2,5-dioneHCID 178512459HCID 178512459, compound

Product 1

HCID 59851292HCID 59851292, compound

Procedure

In a manner similar to that described for method I, 8-chloro-4-dimethylaminomethylene-3,4-dihydro-1H-benzo[b]azepine-2,5-dione (v-j) and N-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-guanidine nitrate were converted to I-28 (71%): HRMS Calcd. for C20H15ClN4O3: 395.091, Found 395.0912.

Sources & evidence

ORD record
ord-7fb22b033283494a8d02deb82fbb702f
Source dataset
uspto-grants-2008_12
Patent number
US07459448B2

Reaction notes

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