8-chloro-4-dimethylaminomethylene-3,4-dihydro-1H-benzo[b]azepine-2,5-dione → HCID 59851263, compound

HRID 2373401Notes

Reaction equation

HRID 2373401 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[C:11](=O)[C:10](=[CH:13]N(C)C)[CH2:9][C:8](=[O:17])[NH:7][C:6]=2[CH:18]=1.[N+]([O-])(O)=O.[CH3:23][C:24]1[CH:25]=[C:26]([NH:31][C:32]([NH2:34])=[NH:33])[CH:27]=[CH:28][C:29]=1[CH3:30]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[C:11]3[N:33]=[C:32]([NH:31][C:26]4[CH:27]=[CH:28][C:29]([CH3:30])=[C:24]([CH3:23])[CH:25]=4)[N:34]=[CH:13][C:10]=3[CH2:9][C:8](=[O:17])[NH:7][C:6]=2[CH:18]=1

Participants

3

Reactant 2

HCID 669348778-chloro-4-dimethylaminomethylene-3,4-dihydro-1H-benzo[b]azepine-2,5-dioneHCID 178426526HCID 178426526, compound

Product 1

HCID 59851263HCID 59851263, compound

Procedure

In a manner similar to that described for method I, 8-chloro-4-dimethylaminomethylene-3,4-dihydro-1H-benzo[b]azepine-2,5-dione (v-j) and N-(3,4-dimethyl-phenyl)-guanidine nitrate were converted to I-29 (59%): HRMS Calcd. for C20H17ClN40: 365.1169, Found 365.1143.

Sources & evidence

ORD record
ord-06014c19421e4fd69c0bd89b37217715
Source dataset
uspto-grants-2008_12
Patent number
US07459448B2

Reaction notes

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