1-(Prop-2-yn-1-yl)pyrrolidine → 9-Chloro-2-[4-(3-pyrrolidin-1-yl-prop-1-ynyl)-phenylamino]-5h,7h benzo[b]pyrimido[4,5-d]azepin-6-one

Participants

Role	Name	HCID	Charge
Reactant	1-(Prop-2-yn-1-yl)pyrrolidine	HCID 299616	—
Reactant	9-Chloro-2-(4-iodo-phenylamino)-5H,7H-benzo[b]pyrimido[4,5-d]azepin-6-one	HCID 56946588	—
Product	9-Chloro-2-[4-(3-pyrrolidin-1-yl-prop-1-ynyl)-phenylamino]-5h,7h benzo[b]pyrimido[4,5-d]azepin-6-one	HCID 59851312	—

Reaction Steps

In a manner similar to that described for Method O, 9-chloro-2-(4-iodo-phenylamino)-5H,7H-benzo[b]pyrimido[4,5-d]azepin-6-one (I-36) and 1-(prop-2-ynyl)pyrrolidine were converted to I-47 (52%): HRMS Calcd. for C25H22ClN5O: 444.1591, Found 444.1589.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07459448B2
Source dataset	uspto-grants-2008_12
ORD ID	ord-152657af8dd14000a77291655c22d371
Source note	uspto-grants-2008_12