HuagongsheHuagongshe Chemistry Print Report · For research reference only
Propargyl alcohol → 9-Chloro-2-[4-(3-hydroxy-prop-1-ynyl)-phenylamino]-5H,7H-benzo[b]pyrimido[4,5-d]azepin-6-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Propargyl alcohol | HCID 7859 | — |
| Reactant | 9-Chloro-2-(4-iodo-phenylamino)-5H,7H-benzo[b]pyrimido[4,5-d]azepin-6-one | HCID 56946588 | — |
| Product | 9-Chloro-2-[4-(3-hydroxy-prop-1-ynyl)-phenylamino]-5H,7H-benzo[b]pyrimido[4,5-d]azepin-6-one | HCID 59851402 | — |
Reaction Steps
In a manner similar to that described for Method O, 9-chloro-2-(4-iodo-phenylamino)-5H,7H-benzo[b]pyrimido[4,5-d]azepin-6-one (I-36) and prop-2-yn-1-ol were converted to I-54 (86%): HRMS Calcd. for C21H15ClN4O2: 391.0961, Found 391.0960.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07459448B2 |
| Source dataset | uspto-grants-2008_12 |
| ORD ID | ord-346ab62cfb32434f8ac2bc911d7574d4 |
| Source note | uspto-grants-2008_12 |