8-chloro-4-dimethylaminomethylene-3,4-dihydro-1H-benzo[b]azepine-2,5-dione → HCID 56946584, compound

HRID 2373410Notes

Reaction equation

HRID 2373410 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[C:11](=O)[C:10](=[CH:13]N(C)C)[CH2:9][C:8](=[O:17])[NH:7][C:6]=2[CH:18]=1.[N+]([O-])(O)=O.[CH3:23][O:24][C:25]1[CH:26]=[C:27]([NH:33][C:34]([NH2:36])=[NH:35])[CH:28]=[C:29]([O:31][CH3:32])[CH:30]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[C:11]3[N:35]=[C:34]([NH:33][C:27]4[CH:28]=[C:29]([O:31][CH3:32])[CH:30]=[C:25]([O:24][CH3:23])[CH:26]=4)[N:36]=[CH:13][C:10]=3[CH2:9][C:8](=[O:17])[NH:7][C:6]=2[CH:18]=1

Participants

3

Reactant 2

HCID 669348778-chloro-4-dimethylaminomethylene-3,4-dihydro-1H-benzo[b]azepine-2,5-dioneHCID 178493229HCID 178493229, compound

Product 1

HCID 56946584HCID 56946584, compound

Procedure

In a manner similar to that described for method I, 8-chloro-4-dimethylaminomethylene-3,4-dihydro-1H-benzo[b]azepine-2,5-dione (v-j) and N-(3,5-dimethoxy-phenyl)-guanidine nitrate were converted to I-55 (62%): HRMS Calcd. for C20H17ClN4O3: 397.1067, Found 397.1056.

Sources & evidence

ORD record
ord-68e9eade2d384191bbcbcd9f2b727690
Source dataset
uspto-grants-2008_12
Patent number
US07459448B2

Reaction notes

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