反应详情

温度

22 °C

To a solution of 9-chloro-2-[4-(3-pyrrolidin-1-yl-prop-1-ynyl)-phenylamino]-5H,7H benzo[b]pyrimido[4,5-d]azepin-6-one (I-47) (0.082 g, 0.19 mmol) in EtOH (5 mL) was added Pd/C (10% wt, ˜50% H2O, 0.01 g) and the mixture was placed under H2 (1 atm) and stirred for 12 h at 22° C. The reaction mixture was filtered through Celite® and the filtrate concentrated in vacuo to give crude product as a yellow oil. Purification by C-18 RP LC-MS chromatography afforded I-66 (0.046 g, 56%):

1. filtrationThe reaction mixture was filtered through Celite®
2. concentrationthe filtrate concentrated in vacuo
3. customto give crude product as a yellow oil
4. customPurification by C-18 RP LC-MS chromatography
5. customafforded I-66 (0.046 g, 56%)