Water → 9-Chloro-2-[4-(3-pyrrolidin-1-yl-propyl)-phenylamino]-5h,7h-benzo[b]pyrimido[4,5-d]-azepin-6-one

HRID 2373411Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[C:11]3[N:12]=[C:13]([NH:16][C:17]4[CH:22]=[CH:21][C:20]([C:23]#[C:24][CH2:25][N:26]5[CH2:30][CH2:29][CH2:28][CH2:27]5)=[CH:19][CH:18]=4)[N:14]=[CH:15][C:10]=3[CH2:9][C:8](=[O:31])[NH:7][C:6]=2[CH:32]=1.O>CCO.[Pd]>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[C:11]3[N:12]=[C:13]([NH:16][C:17]4[CH:18]=[CH:19][C:20]([CH2:23][CH2:24][CH2:25][N:26]5[CH2:27][CH2:28][CH2:29][CH2:30]5)=[CH:21][CH:22]=4)[N:14]=[CH:15][C:10]=3[CH2:9][C:8](=[O:31])[NH:7][C:6]=2[CH:32]=1

Participants

Conditions

Temperature: 22 °C

Procedure

To a solution of 9-chloro-2-[4-(3-pyrrolidin-1-yl-prop-1-ynyl)-phenylamino]-5H,7H benzo[b]pyrimido[4,5-d]azepin-6-one (I-47) (0.082 g, 0.19 mmol) in EtOH (5 mL) was added Pd/C (10% wt, ˜50% H2O, 0.01 g) and the mixture was placed under H2 (1 atm) and stirred for 12 h at 22° C. The reaction mixture was filtered through Celite® and the filtrate concentrated in vacuo to give crude product as a yellow oil. Purification by C-18 RP LC-MS chromatography afforded I-66 (0.046 g, 56%):

Workup

filtrationThe reaction mixture was filtered through Celite®
concentrationthe filtrate concentrated in vacuo
customto give crude product as a yellow oil
customPurification by C-18 RP LC-MS chromatography
customafforded I-66 (0.046 g, 56%)

Sources & evidence

ORD record: ord-0343c52c81ac4297bfa226cc320edab9
Source dataset: uspto-grants-2008_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07459448B2

Reaction notes

Loading…