HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(Prop-2-yn-1-yl)pyrrolidine → 2-(3 4-Dimethoxy-phenylamino)-9-(3-pyrrolidin-1-yl-prop-1-ynyl)-5H,7H benzo[b]pyrimido[4,5-d]azepin-6-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(Prop-2-yn-1-yl)pyrrolidine | HCID 299616 | — |
| Reactant | HCID 56946380 | HCID 56946380 | — |
| Product | 2-(3 4-Dimethoxy-phenylamino)-9-(3-pyrrolidin-1-yl-prop-1-ynyl)-5H,7H benzo[b]pyrimido[4,5-d]azepin-6-one | HCID 59851376 | — |
Reaction Steps
In a manner similar to that described above for Method O, 2-(3,4-dimethoxy-phenylamino)-9-iodo-5H,7H-benzo[b]pyrimido[4,5-d]azepin-6-one (I-30) and 1-(prop-2-ynyl)pyrrolidine were converted to I-32 (42%): HRMS Calcd. for C27H27N5O3: 470.2192, Found 470.2192.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07459448B2 |
| Source dataset | uspto-grants-2008_12 |
| ORD ID | ord-4c3e4523fe304ac88c0c207a724299d1 |
| Source note | uspto-grants-2008_12 |